No, the Lost Mary OS5000 is a disposable vape device, which means it is designed for one-time use and cannot be refilled. Once the e-liquid runs out or the battery dies, the device should be properly disposed of and replaced with a new one. Attempting to refill it can damage the device and may lead to leaks or performance issues. If you're looking for a refillable option, consider a reusable vape system instead.