kirazmattson
1456 posts
Apr 01, 2025
10:51 PM
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Tadalista is a medication used to treat erectile dysfunction (ED) and contains tadalafil as its active ingredient. Tadalafil works by increasing blood flow to the penis, helping men with ED achieve and maintain an erection when sexually stimulated. The way Tadalista works with nitric oxide (NO) levels is central to its mechanism of action. Here's a breakdown of how it works: Sexual Stimulation and Nitric Oxide Release: When a man is sexually aroused, the nervous system releases nitric oxide (NO) in the tissues of the penis. Nitric oxide plays a key role in the erectile process by relaxing the smooth muscles in the blood vessels of the penis. Activation of Guanylate Cyclase: Nitric oxide activates an enzyme called guanylate cyclase, which increases the production of cyclic GMP (cGMP), a molecule that helps relax the smooth muscles in the penile blood vessels. This relaxation allows the blood vessels to expand (dilate), leading to increased blood flow to the penis. How Tadalista (Tadalafil) Enhances this Process: Tadalista works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). PDE5 breaks down cGMP, which can limit the relaxation of the penile muscles and the resulting increase in blood flow. By inhibiting PDE5, tadalafil allows cGMP to persist for longer periods, which maintains smooth muscle relaxation and enhances blood flow to the penis during sexual stimulation.
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